|
KMID : 0357119930150020173
|
|
Korean Journal of Immunology
1993 Volume.15 No. 2 p.173 ~ p.182
|
|
|
The In Vitro Effect of Ultraviolet Radiation on the Production of IL-1 by Human Keratinocyte and the Influence of Retinoid
|
|
Chung Jin-Ho
Eun Hee-Chul
Yoon Jai-Il
|
|
|
Abstract
|
|
|
|
The purpose of this study is to observe the effect of UVB and retinoid on the production of IL-1 in cultured human keratinocytes and to determine whether retinoid can influence the effect of UVB on the IL-1 production. Human keratinocytes derived from normal foreskin were treated with various dose of UVB(0-100mJ/cm2) or retinol acetate(0-5 x 10-6M) and cultured for 1-3 days. IL-i levels in the culture supernatants and cell extracts of the cultured keratinocytes were measured by thymocyte costimulation assay. We demonstrated that UVB and retinol acetate increased the production of IL-1 by human keratinocytes, and the stimulatory effect of UVB on the production of IL -1 in keratinncvt.es was also increased by retinnl acetate.
|
|
|
KEYWORD
|
|
|
UVB, Retinol Acetate, IL-1, Keratinocyte
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|